Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse mod...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A. Giotopoulou, Anthi C. Krontira, Marianthi Iliopoulou, Nikolaos I. Kanellakis, Theodora Agalioti, Anastasios D. Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S. Blackwell, Stavros Taraviras, Magda Spella, Georgios T. Stathopoulos
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/6a500ee17a8443c4ad3c2fbe668a22da
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/6a500ee17a8443c4ad3c2fbe668a22da

Documents similaires