Reproductive fitness and genetic risk of psychiatric disorders in the general population

Why genetic variants that confer risk for psychiatric disorders persist in the genome is an evolutionary conundrum. Here, Mullinset al. report association of polygenic risk for autism with having fewer children and polygenic risk for ADHD with higher reproductive fitness.

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Autores principales:	Niamh Mullins, Andrés Ingason, Heather Porter, Jack Euesden, Alexandra Gillett, Sigurgeir Ólafsson, Daniel F. Gudbjartsson, Cathryn M. Lewis, Engilbert Sigurdsson, Evald Saemundsen, Ólafur Ó Gudmundsson, Michael L. Frigge, Augustine Kong, Agnar Helgason, G. Bragi Walters, Omar Gustafsson, Hreinn Stefansson, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a60e54dd24e47ccb00660d46b48e9ad
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spelling	oai:doaj.org-article:6a60e54dd24e47ccb00660d46b48e9ad2021-12-02T17:01:24ZReproductive fitness and genetic risk of psychiatric disorders in the general population10.1038/ncomms158332041-1723https://doaj.org/article/6a60e54dd24e47ccb00660d46b48e9ad2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15833https://doaj.org/toc/2041-1723Why genetic variants that confer risk for psychiatric disorders persist in the genome is an evolutionary conundrum. Here, Mullinset al. report association of polygenic risk for autism with having fewer children and polygenic risk for ADHD with higher reproductive fitness.Niamh MullinsAndrés IngasonHeather PorterJack EuesdenAlexandra GillettSigurgeir ÓlafssonDaniel F. GudbjartssonCathryn M. LewisEngilbert SigurdssonEvald SaemundsenÓlafur Ó GudmundssonMichael L. FriggeAugustine KongAgnar HelgasonG. Bragi WaltersOmar GustafssonHreinn StefanssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niamh Mullins Andrés Ingason Heather Porter Jack Euesden Alexandra Gillett Sigurgeir Ólafsson Daniel F. Gudbjartsson Cathryn M. Lewis Engilbert Sigurdsson Evald Saemundsen Ólafur Ó Gudmundsson Michael L. Frigge Augustine Kong Agnar Helgason G. Bragi Walters Omar Gustafsson Hreinn Stefansson Kari Stefansson Reproductive fitness and genetic risk of psychiatric disorders in the general population
description	Why genetic variants that confer risk for psychiatric disorders persist in the genome is an evolutionary conundrum. Here, Mullinset al. report association of polygenic risk for autism with having fewer children and polygenic risk for ADHD with higher reproductive fitness.
format	article
author	Niamh Mullins Andrés Ingason Heather Porter Jack Euesden Alexandra Gillett Sigurgeir Ólafsson Daniel F. Gudbjartsson Cathryn M. Lewis Engilbert Sigurdsson Evald Saemundsen Ólafur Ó Gudmundsson Michael L. Frigge Augustine Kong Agnar Helgason G. Bragi Walters Omar Gustafsson Hreinn Stefansson Kari Stefansson
author_facet	Niamh Mullins Andrés Ingason Heather Porter Jack Euesden Alexandra Gillett Sigurgeir Ólafsson Daniel F. Gudbjartsson Cathryn M. Lewis Engilbert Sigurdsson Evald Saemundsen Ólafur Ó Gudmundsson Michael L. Frigge Augustine Kong Agnar Helgason G. Bragi Walters Omar Gustafsson Hreinn Stefansson Kari Stefansson
author_sort	Niamh Mullins
title	Reproductive fitness and genetic risk of psychiatric disorders in the general population
title_short	Reproductive fitness and genetic risk of psychiatric disorders in the general population
title_full	Reproductive fitness and genetic risk of psychiatric disorders in the general population
title_fullStr	Reproductive fitness and genetic risk of psychiatric disorders in the general population
title_full_unstemmed	Reproductive fitness and genetic risk of psychiatric disorders in the general population
title_sort	reproductive fitness and genetic risk of psychiatric disorders in the general population
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6a60e54dd24e47ccb00660d46b48e9ad
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Reproductive fitness and genetic risk of psychiatric disorders in the general population

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