Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal su...

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Autores principales: Nitish Sathyanarayanan, Giuseppe Cannone, Lokesh Gakhar, Nainesh Katagihallimath, Ramanathan Sowdhamini, Subramanian Ramaswamy, Kutti R. Vinothkumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6a6fe31ff0ab4ec58d220d185727fa01
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