Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal su...

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Autores principales:	Nitish Sathyanarayanan, Giuseppe Cannone, Lokesh Gakhar, Nainesh Katagihallimath, Ramanathan Sowdhamini, Subramanian Ramaswamy, Kutti R. Vinothkumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a6fe31ff0ab4ec58d220d185727fa01
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spelling	oai:doaj.org-article:6a6fe31ff0ab4ec58d220d185727fa012021-12-02T15:35:53ZMolecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway10.1038/s41467-019-11931-12041-1723https://doaj.org/article/6a6fe31ff0ab4ec58d220d185727fa012019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11931-1https://doaj.org/toc/2041-1723The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal substrate channeling.Nitish SathyanarayananGiuseppe CannoneLokesh GakharNainesh KatagihallimathRamanathan SowdhaminiSubramanian RamaswamyKutti R. VinothkumarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nitish Sathyanarayanan Giuseppe Cannone Lokesh Gakhar Nainesh Katagihallimath Ramanathan Sowdhamini Subramanian Ramaswamy Kutti R. Vinothkumar Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
description	The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal substrate channeling.
format	article
author	Nitish Sathyanarayanan Giuseppe Cannone Lokesh Gakhar Nainesh Katagihallimath Ramanathan Sowdhamini Subramanian Ramaswamy Kutti R. Vinothkumar
author_facet	Nitish Sathyanarayanan Giuseppe Cannone Lokesh Gakhar Nainesh Katagihallimath Ramanathan Sowdhamini Subramanian Ramaswamy Kutti R. Vinothkumar
author_sort	Nitish Sathyanarayanan
title	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
title_short	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
title_full	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
title_fullStr	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
title_full_unstemmed	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
title_sort	molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6a6fe31ff0ab4ec58d220d185727fa01
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Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

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