Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8

Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8

MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors. Understanding of their function is hampered by three major knowledge gaps: (i) it is unclear which cell types utilize these ligases; (ii) their level of redundancy is unknown; and (iii) m...

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Main Authors: Patrick Schriek, Haiyin Liu, Alan C. Ching, Pauline Huang, Nishma Gupta, Kayla R. Wilson, MinHsuang Tsai, Yuting Yan, Christophe F. Macri, Laura F. Dagley, Giuseppe Infusini, Andrew I. Webb, Hamish E.G. McWilliam, Satoshi Ishido, Justine D. Mintern, Jose A. Villadangos
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Antigen presentation and processing
Regulation of surface stimulatory molecules
MARCH E3 ubiquitin ligases
Primary cell analysis
Specialties of internal medicine
RC581-951
Online Access:https://doaj.org/article/6a717133d4e94e62b63aa75cdf8d87bd
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https://doaj.org/article/6a717133d4e94e62b63aa75cdf8d87bd

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