Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

<h4>Background</h4>PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor gene implicated in a wide variety of human cancers, including glioblastoma. PTEN is a major negative regulator of the PI3K/Akt signaling pathway. Most human gliomas show high levels...

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Bibliographic Details
Main Authors: Venkata Ramesh Dasari, Kiranpreet Kaur, Kiran Kumar Velpula, Meena Gujrati, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Jasti S Rao
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/6a723fced9cd4221ac9ea13f1a9d2f8e
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