Enhanced oncolytic adenoviral production by downregulation of death-domain associated protein and overexpression of precursor terminal protein

Abstract Adequate viral replication in tumor cells is the key to improving the anti-cancer effects of oncolytic adenovirus therapy. In this study, we introduced short hairpin RNAs against death-domain associated protein (Daxx), a repressor of adenoviral replication, and precursor terminal protein (p...

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Autores principales: Jihyun Lee, Geun-Hyeok Oh, Jeong A. Hong, Soojin Choi, Hye Jin Choi, Jae J. Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6a774af5ee9d4227a13925858eb8e247
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