Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment

Abstract Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs) possess a great therapeutical potential for osteoarthritis (OA) treatment. However, the steric and electrostatic hindrance of cartilage matrix leads to very limited distribution of MSC‐sEVs in cartilage and low bioavailab...

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Auteurs principaux: Kai Feng, Xuetao Xie, Ji Yuan, Liangzhi Gong, Zhaochen Zhu, Juntao Zhang, Haiyan Li, Yunlong Yang, Yang Wang
Format: article
Langue:EN
Publié: Taylor & Francis Group 2021
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Accès en ligne:https://doaj.org/article/6a7f985ad6924ca88ea07e67d789fe61
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