Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

Long-read sequencing is useful in determining exon-connectivity of full-length mRNA isoforms. Here, by long-read nanopore sequencing, the authors report that intron retention is downregulated in SF3B1 mutant chronic lymphocytic leukemia cells than normal B cells.

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Autores principales:	Alison D. Tang, Cameron M. Soulette, Marijke J. van Baren, Kevyn Hart, Eva Hrabeta-Robinson, Catherine J. Wu, Angela N. Brooks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a806ecaedad4c65b48bc9c6561be042
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spelling	oai:doaj.org-article:6a806ecaedad4c65b48bc9c6561be0422021-12-02T15:33:53ZFull-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns10.1038/s41467-020-15171-62041-1723https://doaj.org/article/6a806ecaedad4c65b48bc9c6561be0422020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15171-6https://doaj.org/toc/2041-1723Long-read sequencing is useful in determining exon-connectivity of full-length mRNA isoforms. Here, by long-read nanopore sequencing, the authors report that intron retention is downregulated in SF3B1 mutant chronic lymphocytic leukemia cells than normal B cells.Alison D. TangCameron M. SouletteMarijke J. van BarenKevyn HartEva Hrabeta-RobinsonCatherine J. WuAngela N. BrooksNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alison D. Tang Cameron M. Soulette Marijke J. van Baren Kevyn Hart Eva Hrabeta-Robinson Catherine J. Wu Angela N. Brooks Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
description	Long-read sequencing is useful in determining exon-connectivity of full-length mRNA isoforms. Here, by long-read nanopore sequencing, the authors report that intron retention is downregulated in SF3B1 mutant chronic lymphocytic leukemia cells than normal B cells.
format	article
author	Alison D. Tang Cameron M. Soulette Marijke J. van Baren Kevyn Hart Eva Hrabeta-Robinson Catherine J. Wu Angela N. Brooks
author_facet	Alison D. Tang Cameron M. Soulette Marijke J. van Baren Kevyn Hart Eva Hrabeta-Robinson Catherine J. Wu Angela N. Brooks
author_sort	Alison D. Tang
title	Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
title_short	Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
title_full	Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
title_fullStr	Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
title_full_unstemmed	Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
title_sort	full-length transcript characterization of sf3b1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6a806ecaedad4c65b48bc9c6561be042
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Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

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