Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved...

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Autores principales:	Kristine Williams, Lars R. Ingerslev, Jette Bork-Jensen, Martin Wohlwend, Ann Normann Hansen, Lewin Small, Rasmus Ribel-Madsen, Arne Astrup, Oluf Pedersen, Johan Auwerx, Christopher T. Workman, Niels Grarup, Torben Hansen, Romain Barrès
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a8adde43f8e4a568fb7abbf52f498c8
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spelling	oai:doaj.org-article:6a8adde43f8e4a568fb7abbf52f498c82021-12-02T15:56:39ZSkeletal muscle enhancer interactions identify genes controlling whole-body metabolism10.1038/s41467-020-16537-62041-1723https://doaj.org/article/6a8adde43f8e4a568fb7abbf52f498c82020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16537-6https://doaj.org/toc/2041-1723Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved in metabolic dysfunction in skeletal muscle.Kristine WilliamsLars R. IngerslevJette Bork-JensenMartin WohlwendAnn Normann HansenLewin SmallRasmus Ribel-MadsenArne AstrupOluf PedersenJohan AuwerxChristopher T. WorkmanNiels GrarupTorben HansenRomain BarrèsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristine Williams Lars R. Ingerslev Jette Bork-Jensen Martin Wohlwend Ann Normann Hansen Lewin Small Rasmus Ribel-Madsen Arne Astrup Oluf Pedersen Johan Auwerx Christopher T. Workman Niels Grarup Torben Hansen Romain Barrès Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
description	Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved in metabolic dysfunction in skeletal muscle.
format	article
author	Kristine Williams Lars R. Ingerslev Jette Bork-Jensen Martin Wohlwend Ann Normann Hansen Lewin Small Rasmus Ribel-Madsen Arne Astrup Oluf Pedersen Johan Auwerx Christopher T. Workman Niels Grarup Torben Hansen Romain Barrès
author_facet	Kristine Williams Lars R. Ingerslev Jette Bork-Jensen Martin Wohlwend Ann Normann Hansen Lewin Small Rasmus Ribel-Madsen Arne Astrup Oluf Pedersen Johan Auwerx Christopher T. Workman Niels Grarup Torben Hansen Romain Barrès
author_sort	Kristine Williams
title	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
title_short	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
title_full	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
title_fullStr	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
title_full_unstemmed	Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
title_sort	skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6a8adde43f8e4a568fb7abbf52f498c8
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Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

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