A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment

Abstract High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels are influenced by both genes and the environment. The aim was to investigate whether education and income as indicators of socioeconomic position (SEP) interact with...

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Autores principales:	Carina Emmel, Mirjam Frank, Nico Dragano, Markus M. Nöthen, Raimund Erbel, Karl-Heinz Jöckel, Börge Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a9002c19e484e1fae7007c5d0181e41
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spelling	oai:doaj.org-article:6a9002c19e484e1fae7007c5d0181e412021-12-02T17:08:43ZA genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment10.1038/s41598-021-95970-z2045-2322https://doaj.org/article/6a9002c19e484e1fae7007c5d0181e412021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95970-zhttps://doaj.org/toc/2045-2322Abstract High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels are influenced by both genes and the environment. The aim was to investigate whether education and income as indicators of socioeconomic position (SEP) interact with lipid-increasing genetic effect allele scores (GES) in a population-based cohort. Using baseline data of 4516 study participants, age- and sex-adjusted linear regression models were fitted to investigate associations between GES and lipids stratified by SEP as well as including GES×SEP interaction terms. In the highest education group compared to the lowest stronger effects per GES standard deviation were observed for HDL-C (2.96 mg/dl [95%-CI: 2.19, 3.83] vs. 2.45 mg/dl [95%-CI: 1.12, 3.72]), LDL-C (6.57 mg/dl [95%-CI: 4.73, 8.37] vs. 2.66 mg/dl [95%-CI: −0.50, 5.76]) and TC (8.06 mg/dl [95%-CI: 6.14, 9.98] vs. 4.37 mg/dl [95%-CI: 0.94, 7.80]). Using the highest education group as reference, interaction terms showed indication of GES by low education interaction for LDL-C (ßGES×Education: −3.87; 95%-CI: −7.47, −0.32), which was slightly attenuated after controlling for GESLDL-C×Diabetes interaction (ßGES×Education: −3.42; 95%-CI: −6.98, 0.18). The present study showed stronger genetic effects on LDL-C in higher SEP groups and gave indication for a GESLDL-C×Education interaction, demonstrating the relevance of SEP for the expression of genetic health risks.Carina EmmelMirjam FrankNico DraganoMarkus M. NöthenRaimund ErbelKarl-Heinz JöckelBörge SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carina Emmel Mirjam Frank Nico Dragano Markus M. Nöthen Raimund Erbel Karl-Heinz Jöckel Börge Schmidt A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
description	Abstract High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels are influenced by both genes and the environment. The aim was to investigate whether education and income as indicators of socioeconomic position (SEP) interact with lipid-increasing genetic effect allele scores (GES) in a population-based cohort. Using baseline data of 4516 study participants, age- and sex-adjusted linear regression models were fitted to investigate associations between GES and lipids stratified by SEP as well as including GES×SEP interaction terms. In the highest education group compared to the lowest stronger effects per GES standard deviation were observed for HDL-C (2.96 mg/dl [95%-CI: 2.19, 3.83] vs. 2.45 mg/dl [95%-CI: 1.12, 3.72]), LDL-C (6.57 mg/dl [95%-CI: 4.73, 8.37] vs. 2.66 mg/dl [95%-CI: −0.50, 5.76]) and TC (8.06 mg/dl [95%-CI: 6.14, 9.98] vs. 4.37 mg/dl [95%-CI: 0.94, 7.80]). Using the highest education group as reference, interaction terms showed indication of GES by low education interaction for LDL-C (ßGES×Education: −3.87; 95%-CI: −7.47, −0.32), which was slightly attenuated after controlling for GESLDL-C×Diabetes interaction (ßGES×Education: −3.42; 95%-CI: −6.98, 0.18). The present study showed stronger genetic effects on LDL-C in higher SEP groups and gave indication for a GESLDL-C×Education interaction, demonstrating the relevance of SEP for the expression of genetic health risks.
format	article
author	Carina Emmel Mirjam Frank Nico Dragano Markus M. Nöthen Raimund Erbel Karl-Heinz Jöckel Börge Schmidt
author_facet	Carina Emmel Mirjam Frank Nico Dragano Markus M. Nöthen Raimund Erbel Karl-Heinz Jöckel Börge Schmidt
author_sort	Carina Emmel
title	A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
title_short	A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
title_full	A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
title_fullStr	A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
title_full_unstemmed	A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
title_sort	genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a9002c19e484e1fae7007c5d0181e41
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A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment

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