Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation

Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation

Sepsis remains a major cause of mortality and morbidity in intensive care units. Dexmedetomidine (DEX) has been reported to attenuate cecal ligation perforation (CLP)-stimulated acute lung injury (ALI) by downregulating high-mobility group protein 1 (HMGB1) and receptor for advanced glycation end pr...

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Bibliographic Details
Main Authors: Huaqin Sun, Hongyi Hu, Xiaoping Xu, Mingsun Fang, Tao Tao, Zhehao Liang
Format: article
Language:EN
Published: Taylor & Francis Group 2021
Subjects:
dexmedetomidine
acute lung injury
hmgb1
rage
nf-κb
pyroptosis
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/6ac67c1f8d094b458a6af15a2e0a6b7e
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