Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila

Abstract Life‐history theory posits that investment into reproduction might occur at the expense of investment into somatic maintenance, including immune function. If so, reduced or curtailed reproductive effort might be expected to increase immunity. In support of this notion, work in Caenorhabditi...

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Main Authors:	Marisa A. Rodrigues, Antoine Merckelbach, Esra Durmaz, Envel Kerdaffrec, Thomas Flatt
Format:	article
Language:	EN
Published:	Wiley 2021
Subjects:	Costs of reproduction gene expression germline immunity trade‐offs Evolution QH359-425
Online Access:	https://doaj.org/article/6b7e013068a240a2a215ae0dba44e3b6
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spelling	oai:doaj.org-article:6b7e013068a240a2a215ae0dba44e3b62021-12-05T14:03:53ZTranscriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila2056-374410.1002/evl3.261https://doaj.org/article/6b7e013068a240a2a215ae0dba44e3b62021-12-01T00:00:00Zhttps://doi.org/10.1002/evl3.261https://doaj.org/toc/2056-3744Abstract Life‐history theory posits that investment into reproduction might occur at the expense of investment into somatic maintenance, including immune function. If so, reduced or curtailed reproductive effort might be expected to increase immunity. In support of this notion, work in Caenorhabditis elegans has shown that worms lacking a germline exhibit improved immunity, but whether the antagonistic relation between germline proliferation and immunity also holds for other organisms is less well understood. Here, we report that transgenic ablation of germ cells in late development or early adulthood in Drosophila melanogaster causes elevated baseline expression and increased induction of Toll and Imd immune genes upon bacterial infection, as compared to fertile flies with an intact germline. We also identify immune genes whose expression after infection differs between fertile and germline‐less flies in a manner that is conditional on their mating status. We conclude that germline activity strongly impedes the expression and inducibility of immune genes and that this physiological trade‐off might be evolutionarily conserved.Marisa A. RodriguesAntoine MerckelbachEsra DurmazEnvel KerdaffrecThomas FlattWileyarticleCosts of reproductiongene expressiongermlineimmunitytrade‐offsEvolutionQH359-425ENEvolution Letters, Vol 5, Iss 6, Pp 644-656 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Costs of reproduction gene expression germline immunity trade‐offs Evolution QH359-425
spellingShingle	Costs of reproduction gene expression germline immunity trade‐offs Evolution QH359-425 Marisa A. Rodrigues Antoine Merckelbach Esra Durmaz Envel Kerdaffrec Thomas Flatt Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
description	Abstract Life‐history theory posits that investment into reproduction might occur at the expense of investment into somatic maintenance, including immune function. If so, reduced or curtailed reproductive effort might be expected to increase immunity. In support of this notion, work in Caenorhabditis elegans has shown that worms lacking a germline exhibit improved immunity, but whether the antagonistic relation between germline proliferation and immunity also holds for other organisms is less well understood. Here, we report that transgenic ablation of germ cells in late development or early adulthood in Drosophila melanogaster causes elevated baseline expression and increased induction of Toll and Imd immune genes upon bacterial infection, as compared to fertile flies with an intact germline. We also identify immune genes whose expression after infection differs between fertile and germline‐less flies in a manner that is conditional on their mating status. We conclude that germline activity strongly impedes the expression and inducibility of immune genes and that this physiological trade‐off might be evolutionarily conserved.
format	article
author	Marisa A. Rodrigues Antoine Merckelbach Esra Durmaz Envel Kerdaffrec Thomas Flatt
author_facet	Marisa A. Rodrigues Antoine Merckelbach Esra Durmaz Envel Kerdaffrec Thomas Flatt
author_sort	Marisa A. Rodrigues
title	Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
title_short	Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
title_full	Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
title_fullStr	Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
title_full_unstemmed	Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila
title_sort	transcriptomic evidence for a trade‐off between germline proliferation and immunity in drosophila
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/6b7e013068a240a2a215ae0dba44e3b6
work_keys_str_mv	AT marisaarodrigues transcriptomicevidenceforatradeoffbetweengermlineproliferationandimmunityindrosophila AT antoinemerckelbach transcriptomicevidenceforatradeoffbetweengermlineproliferationandimmunityindrosophila AT esradurmaz transcriptomicevidenceforatradeoffbetweengermlineproliferationandimmunityindrosophila AT envelkerdaffrec transcriptomicevidenceforatradeoffbetweengermlineproliferationandimmunityindrosophila AT thomasflatt transcriptomicevidenceforatradeoffbetweengermlineproliferationandimmunityindrosophila
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Transcriptomic evidence for a trade‐off between germline proliferation and immunity in Drosophila

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