Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the...

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Autores principales:	Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber, Boris Hadaschik, Sascha Pahernik, Wilfried Roth, Roland Eils, Matthias Schlesner, Holger Sültmann, Markus Hohenfellner, Niels Grabe, Stefan Duensing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72
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spelling	oai:doaj.org-article:6b8b3ea588cd4746baa64e76cce15f722021-12-02T15:35:22ZSpatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity10.1038/ncomms118452041-1723https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f722016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11845https://doaj.org/toc/2041-1723It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the tumour.Rouven HoefflinBernd LahrmannGregor WarsowDaniel HübschmannCathleen SpathBritta WalterXin ChenLuisa HoferStephan Macher-GoeppingerYanis TolstovNina KorzeniewskiAnette DuensingCarsten GrüllichDirk JägerSven PernerGita SchönbergJoanne Nyarangi-DixSanjay IsaacGencay HatibogluDogu TeberBoris HadaschikSascha PahernikWilfried RothRoland EilsMatthias SchlesnerHolger SültmannMarkus HohenfellnerNiels GrabeStefan DuensingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rouven Hoefflin Bernd Lahrmann Gregor Warsow Daniel Hübschmann Cathleen Spath Britta Walter Xin Chen Luisa Hofer Stephan Macher-Goeppinger Yanis Tolstov Nina Korzeniewski Anette Duensing Carsten Grüllich Dirk Jäger Sven Perner Gita Schönberg Joanne Nyarangi-Dix Sanjay Isaac Gencay Hatiboglu Dogu Teber Boris Hadaschik Sascha Pahernik Wilfried Roth Roland Eils Matthias Schlesner Holger Sültmann Markus Hohenfellner Niels Grabe Stefan Duensing Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
description	It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the tumour.
format	article
author	Rouven Hoefflin Bernd Lahrmann Gregor Warsow Daniel Hübschmann Cathleen Spath Britta Walter Xin Chen Luisa Hofer Stephan Macher-Goeppinger Yanis Tolstov Nina Korzeniewski Anette Duensing Carsten Grüllich Dirk Jäger Sven Perner Gita Schönberg Joanne Nyarangi-Dix Sanjay Isaac Gencay Hatiboglu Dogu Teber Boris Hadaschik Sascha Pahernik Wilfried Roth Roland Eils Matthias Schlesner Holger Sültmann Markus Hohenfellner Niels Grabe Stefan Duensing
author_facet	Rouven Hoefflin Bernd Lahrmann Gregor Warsow Daniel Hübschmann Cathleen Spath Britta Walter Xin Chen Luisa Hofer Stephan Macher-Goeppinger Yanis Tolstov Nina Korzeniewski Anette Duensing Carsten Grüllich Dirk Jäger Sven Perner Gita Schönberg Joanne Nyarangi-Dix Sanjay Isaac Gencay Hatiboglu Dogu Teber Boris Hadaschik Sascha Pahernik Wilfried Roth Roland Eils Matthias Schlesner Holger Sültmann Markus Hohenfellner Niels Grabe Stefan Duensing
author_sort	Rouven Hoefflin
title	Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
title_short	Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
title_full	Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
title_fullStr	Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
title_full_unstemmed	Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
title_sort	spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72
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Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

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