Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect

Although antisense oligonucleotide (ASO) therapeutics can be taken up by living cells without carrier molecules, a large part of incorporated ASOs are trapped in the endosomes and do not exert therapeutic effects. To improve their therapeutic effects, it would be important to elucidate the mechanism...

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Autores principales: Masayuki Takahashi, Mineaki Seki, Masayuki Nashimoto, Tomohiro Kabuta
Formato: article
Lenguaje:EN
Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/6bbd43e111d942ffb5f9e3594e13f4dc
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