Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.

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Detalles Bibliográficos
Autores principales: Taek-Chin Cheong, Mara Compagno, Roberto Chiarle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/6bcc873a3691474593b9a5309921326e
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