Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.

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Detalles Bibliográficos
Autores principales:	Taek-Chin Cheong, Mara Compagno, Roberto Chiarle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bcc873a3691474593b9a5309921326e
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id	oai:doaj.org-article:6bcc873a3691474593b9a5309921326e
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spelling	oai:doaj.org-article:6bcc873a3691474593b9a5309921326e2021-12-02T14:39:12ZEditing of mouse and human immunoglobulin genes by CRISPR-Cas9 system10.1038/ncomms109342041-1723https://doaj.org/article/6bcc873a3691474593b9a5309921326e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10934https://doaj.org/toc/2041-1723CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.Taek-Chin CheongMara CompagnoRoberto ChiarleNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taek-Chin Cheong Mara Compagno Roberto Chiarle Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
description	CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.
format	article
author	Taek-Chin Cheong Mara Compagno Roberto Chiarle
author_facet	Taek-Chin Cheong Mara Compagno Roberto Chiarle
author_sort	Taek-Chin Cheong
title	Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
title_short	Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
title_full	Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
title_fullStr	Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
title_full_unstemmed	Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
title_sort	editing of mouse and human immunoglobulin genes by crispr-cas9 system
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6bcc873a3691474593b9a5309921326e
work_keys_str_mv	AT taekchincheong editingofmouseandhumanimmunoglobulingenesbycrisprcas9system AT maracompagno editingofmouseandhumanimmunoglobulingenesbycrisprcas9system AT robertochiarle editingofmouseandhumanimmunoglobulingenesbycrisprcas9system
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Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

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