Posttranslational chemical installation of azoles into translated peptides

Azoles are five-membered heterocycles found in peptidic natural products and synthetic peptiodomimetics. Here the authors demonstrate a posttranslational chemical modification method for in vitro ribosomal synthesis of peptides with exotic azole groups at specific positions.

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Autores principales:	Haruka Tsutsumi, Tomohiro Kuroda, Hiroyuki Kimura, Yuki Goto, Hiroaki Suga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bddf073720e4273a7a78d0eb520df7e
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spelling	oai:doaj.org-article:6bddf073720e4273a7a78d0eb520df7e2021-12-02T13:24:04ZPosttranslational chemical installation of azoles into translated peptides10.1038/s41467-021-20992-02041-1723https://doaj.org/article/6bddf073720e4273a7a78d0eb520df7e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20992-0https://doaj.org/toc/2041-1723Azoles are five-membered heterocycles found in peptidic natural products and synthetic peptiodomimetics. Here the authors demonstrate a posttranslational chemical modification method for in vitro ribosomal synthesis of peptides with exotic azole groups at specific positions.Haruka TsutsumiTomohiro KurodaHiroyuki KimuraYuki GotoHiroaki SugaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haruka Tsutsumi Tomohiro Kuroda Hiroyuki Kimura Yuki Goto Hiroaki Suga Posttranslational chemical installation of azoles into translated peptides
description	Azoles are five-membered heterocycles found in peptidic natural products and synthetic peptiodomimetics. Here the authors demonstrate a posttranslational chemical modification method for in vitro ribosomal synthesis of peptides with exotic azole groups at specific positions.
format	article
author	Haruka Tsutsumi Tomohiro Kuroda Hiroyuki Kimura Yuki Goto Hiroaki Suga
author_facet	Haruka Tsutsumi Tomohiro Kuroda Hiroyuki Kimura Yuki Goto Hiroaki Suga
author_sort	Haruka Tsutsumi
title	Posttranslational chemical installation of azoles into translated peptides
title_short	Posttranslational chemical installation of azoles into translated peptides
title_full	Posttranslational chemical installation of azoles into translated peptides
title_fullStr	Posttranslational chemical installation of azoles into translated peptides
title_full_unstemmed	Posttranslational chemical installation of azoles into translated peptides
title_sort	posttranslational chemical installation of azoles into translated peptides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6bddf073720e4273a7a78d0eb520df7e
work_keys_str_mv	AT harukatsutsumi posttranslationalchemicalinstallationofazolesintotranslatedpeptides AT tomohirokuroda posttranslationalchemicalinstallationofazolesintotranslatedpeptides AT hiroyukikimura posttranslationalchemicalinstallationofazolesintotranslatedpeptides AT yukigoto posttranslationalchemicalinstallationofazolesintotranslatedpeptides AT hiroakisuga posttranslationalchemicalinstallationofazolesintotranslatedpeptides
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Posttranslational chemical installation of azoles into translated peptides

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