Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to regulate transcription. Here the authors present engineered mouse ESCs targeting the PRC2 subunits EZH1 and EZH2 to discriminate between contributions of distinct H3K27 methylation states and the presence of PRC2/1 at...

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Auteurs principaux: Elisa Lavarone, Caterina M. Barbieri, Diego Pasini
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/6bf947098d2c42f4b5b4f596c4629b74
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