Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to regulate transcription. Here the authors present engineered mouse ESCs targeting the PRC2 subunits EZH1 and EZH2 to discriminate between contributions of distinct H3K27 methylation states and the presence of PRC2/1 at...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elisa Lavarone, Caterina M. Barbieri, Diego Pasini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bf947098d2c42f4b5b4f596c4629b74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6bf947098d2c42f4b5b4f596c4629b74
record_format	dspace
spelling	oai:doaj.org-article:6bf947098d2c42f4b5b4f596c4629b742021-12-02T17:01:32ZDissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity10.1038/s41467-019-09624-w2041-1723https://doaj.org/article/6bf947098d2c42f4b5b4f596c4629b742019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09624-whttps://doaj.org/toc/2041-1723Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to regulate transcription. Here the authors present engineered mouse ESCs targeting the PRC2 subunits EZH1 and EZH2 to discriminate between contributions of distinct H3K27 methylation states and the presence of PRC2/1 at chromatin, and provide evidence for the role of H3K27 acetylation in PRC2-mediated functions.Elisa LavaroneCaterina M. BarbieriDiego PasiniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisa Lavarone Caterina M. Barbieri Diego Pasini Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
description	Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to regulate transcription. Here the authors present engineered mouse ESCs targeting the PRC2 subunits EZH1 and EZH2 to discriminate between contributions of distinct H3K27 methylation states and the presence of PRC2/1 at chromatin, and provide evidence for the role of H3K27 acetylation in PRC2-mediated functions.
format	article
author	Elisa Lavarone Caterina M. Barbieri Diego Pasini
author_facet	Elisa Lavarone Caterina M. Barbieri Diego Pasini
author_sort	Elisa Lavarone
title	Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
title_short	Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
title_full	Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
title_fullStr	Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
title_full_unstemmed	Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
title_sort	dissecting the role of h3k27 acetylation and methylation in prc2 mediated control of cellular identity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6bf947098d2c42f4b5b4f596c4629b74
work_keys_str_mv	AT elisalavarone dissectingtheroleofh3k27acetylationandmethylationinprc2mediatedcontrolofcellularidentity AT caterinambarbieri dissectingtheroleofh3k27acetylationandmethylationinprc2mediatedcontrolofcellularidentity AT diegopasini dissectingtheroleofh3k27acetylationandmethylationinprc2mediatedcontrolofcellularidentity
_version_	1718382088458076160

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

Ejemplares similares