Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

Systems pharmacology:Predicting efficacy of novel anti-cancer drugs in colorectal cancer While cancer drug development relies on experimental tumor models for testing, results observed in these systems often fail to translate clinically. Kirouac et al. demonstrate how computational systems modelling...

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Bibliographic Details
Main Authors: Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/6bfc02d0615b4d33ac88a7be2e3e419b
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