Minimal lactazole scaffold for in vitro thiopeptide bioengineering

Lactazole A is a thiopeptide from Streptomyces lactacystinaeus, encoded by a compact 9.8 kb biosynthetic gene cluster. Here, the authors show a platform for in vitro biosynthesis of lactazole A via a combination of a flexible in vitro translation system with recombinantly produced lactazole biosynth...

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Autores principales:	Alexander A. Vinogradov, Morito Shimomura, Yuki Goto, Taro Ozaki, Shumpei Asamizu, Yoshinori Sugai, Hiroaki Suga, Hiroyasu Onaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c035ecbb8cf4f339e7220fe64bdc375
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spelling	oai:doaj.org-article:6c035ecbb8cf4f339e7220fe64bdc3752021-12-02T17:32:42ZMinimal lactazole scaffold for in vitro thiopeptide bioengineering10.1038/s41467-020-16145-42041-1723https://doaj.org/article/6c035ecbb8cf4f339e7220fe64bdc3752020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16145-4https://doaj.org/toc/2041-1723Lactazole A is a thiopeptide from Streptomyces lactacystinaeus, encoded by a compact 9.8 kb biosynthetic gene cluster. Here, the authors show a platform for in vitro biosynthesis of lactazole A via a combination of a flexible in vitro translation system with recombinantly produced lactazole biosynthetic enzymes.Alexander A. VinogradovMorito ShimomuraYuki GotoTaro OzakiShumpei AsamizuYoshinori SugaiHiroaki SugaHiroyasu OnakaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander A. Vinogradov Morito Shimomura Yuki Goto Taro Ozaki Shumpei Asamizu Yoshinori Sugai Hiroaki Suga Hiroyasu Onaka Minimal lactazole scaffold for in vitro thiopeptide bioengineering
description	Lactazole A is a thiopeptide from Streptomyces lactacystinaeus, encoded by a compact 9.8 kb biosynthetic gene cluster. Here, the authors show a platform for in vitro biosynthesis of lactazole A via a combination of a flexible in vitro translation system with recombinantly produced lactazole biosynthetic enzymes.
format	article
author	Alexander A. Vinogradov Morito Shimomura Yuki Goto Taro Ozaki Shumpei Asamizu Yoshinori Sugai Hiroaki Suga Hiroyasu Onaka
author_facet	Alexander A. Vinogradov Morito Shimomura Yuki Goto Taro Ozaki Shumpei Asamizu Yoshinori Sugai Hiroaki Suga Hiroyasu Onaka
author_sort	Alexander A. Vinogradov
title	Minimal lactazole scaffold for in vitro thiopeptide bioengineering
title_short	Minimal lactazole scaffold for in vitro thiopeptide bioengineering
title_full	Minimal lactazole scaffold for in vitro thiopeptide bioengineering
title_fullStr	Minimal lactazole scaffold for in vitro thiopeptide bioengineering
title_full_unstemmed	Minimal lactazole scaffold for in vitro thiopeptide bioengineering
title_sort	minimal lactazole scaffold for in vitro thiopeptide bioengineering
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c035ecbb8cf4f339e7220fe64bdc375
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Minimal lactazole scaffold for in vitro thiopeptide bioengineering

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