Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption

Abstract In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their biologically-active conformations and minimum motifs for function represents a requisite step to de...

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Autores principales: Fatih Comert, Frank Heinrich, Ananda Chowdhury, Mason Schoeneck, Caitlin Darling, Kyle W. Anderson, M. Daben J. Libardo, Alfredo M. Angeles-Boza, Vitalii Silin, Myriam L. Cotten, Mihaela Mihailescu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6c1a2a9787704316b967c97b4adbe0f9
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