Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational chan...

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Autores principales:	Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
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spelling	oai:doaj.org-article:6c1b5d05ad4143f2afd6b9134b37d8022021-12-02T14:35:51ZCrystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists10.1038/s41467-018-07939-82041-1723https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d8022019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07939-8https://doaj.org/toc/2041-1723Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.Jendrik SchöppeJanosch EhrenmannChristoph KlenkPrakash RucktooaMarco SchützAndrew S. DoréAndreas PlückthunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
description	Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.
format	article
author	Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun
author_facet	Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun
author_sort	Jendrik Schöppe
title	Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_short	Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_full	Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_fullStr	Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_full_unstemmed	Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_sort	crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
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Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

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