Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational chan...

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Autores principales: Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
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spelling oai:doaj.org-article:6c1b5d05ad4143f2afd6b9134b37d8022021-12-02T14:35:51ZCrystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists10.1038/s41467-018-07939-82041-1723https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d8022019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07939-8https://doaj.org/toc/2041-1723Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.Jendrik SchöppeJanosch EhrenmannChristoph KlenkPrakash RucktooaMarco SchützAndrew S. DoréAndreas PlückthunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jendrik Schöppe
Janosch Ehrenmann
Christoph Klenk
Prakash Rucktooa
Marco Schütz
Andrew S. Doré
Andreas Plückthun
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
description Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.
format article
author Jendrik Schöppe
Janosch Ehrenmann
Christoph Klenk
Prakash Rucktooa
Marco Schütz
Andrew S. Doré
Andreas Plückthun
author_facet Jendrik Schöppe
Janosch Ehrenmann
Christoph Klenk
Prakash Rucktooa
Marco Schütz
Andrew S. Doré
Andreas Plückthun
author_sort Jendrik Schöppe
title Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_short Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_full Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_fullStr Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_full_unstemmed Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
title_sort crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
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