Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational chan...
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Nature Portfolio
2019
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oai:doaj.org-article:6c1b5d05ad4143f2afd6b9134b37d8022021-12-02T14:35:51ZCrystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists10.1038/s41467-018-07939-82041-1723https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d8022019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07939-8https://doaj.org/toc/2041-1723Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor.Jendrik SchöppeJanosch EhrenmannChristoph KlenkPrakash RucktooaMarco SchützAndrew S. DoréAndreas PlückthunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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Science Q Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
description |
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically approved compounds induce a conformational change in the receptor. |
format |
article |
author |
Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun |
author_facet |
Jendrik Schöppe Janosch Ehrenmann Christoph Klenk Prakash Rucktooa Marco Schütz Andrew S. Doré Andreas Plückthun |
author_sort |
Jendrik Schöppe |
title |
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
title_short |
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
title_full |
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
title_fullStr |
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
title_full_unstemmed |
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
title_sort |
crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802 |
work_keys_str_mv |
AT jendrikschoppe crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT janoschehrenmann crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT christophklenk crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT prakashrucktooa crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT marcoschutz crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT andrewsdore crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists AT andreaspluckthun crystalstructuresofthehumanneurokinin1receptorincomplexwithclinicallyusedantagonists |
_version_ |
1718391011588177920 |