Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

ABSTRACT To transfer the viral genome into the host cell cytoplasm, internalized influenza A virus (IAV) particles depend on the fusion of the IAV envelope with host endosomal membranes. The antiviral host interferon (IFN) response includes the upregulation of interferon-induced transmembrane protei...

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Auteurs principaux: Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
Format: article
Langue:EN
Publié: American Society for Microbiology 2018
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Accès en ligne:https://doaj.org/article/6c3d712588c4446f9847a58b5227d3c0
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