Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis

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Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis

Doxorubicin (Dox) is a chemotherapeutic agent with cardiotoxicity associated with profibrotic effects. Dox increases ceramide levels with pro-inflammatory effects, cell death, and fibrosis. The purpose of our study was to identify the underlying ceramide signaling pathways. We aimed to characterize...

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Auteurs principaux:	Tom Kretzschmar, Mohamed M. Bekhite, Jasmine M. F. Wu, Daniela Haase, Martin Förster, Tina Müller, Sandor Nietzsche, Martin Westermann, Marcus Franz, Markus H. Gräler, P. Christian Schulze
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	ceramides reactive oxygen species fibrosis mitochondrial function respiratory chain Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/6c46b5dcf5a94933a40b90adf86c3617
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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