Estimating growth patterns and driver effects in tumor evolution from individual samples

There are many methods to detect cancer-driving mutations. Here, the authors harness the variant allele frequency of mutations in tumor cells of a single individual to present a method that can estimate growth patterns and identify driver gene evolution at a patient specific level.

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Autores principales:	Leonidas Salichos, William Meyerson, Jonathan Warrell, Mark Gerstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c6a5bf56eac4983a05e8f4f824a7d1c
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spelling	oai:doaj.org-article:6c6a5bf56eac4983a05e8f4f824a7d1c2021-12-02T15:39:11ZEstimating growth patterns and driver effects in tumor evolution from individual samples10.1038/s41467-020-14407-92041-1723https://doaj.org/article/6c6a5bf56eac4983a05e8f4f824a7d1c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14407-9https://doaj.org/toc/2041-1723There are many methods to detect cancer-driving mutations. Here, the authors harness the variant allele frequency of mutations in tumor cells of a single individual to present a method that can estimate growth patterns and identify driver gene evolution at a patient specific level.Leonidas SalichosWilliam MeyersonJonathan WarrellMark GersteinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonidas Salichos William Meyerson Jonathan Warrell Mark Gerstein Estimating growth patterns and driver effects in tumor evolution from individual samples
description	There are many methods to detect cancer-driving mutations. Here, the authors harness the variant allele frequency of mutations in tumor cells of a single individual to present a method that can estimate growth patterns and identify driver gene evolution at a patient specific level.
format	article
author	Leonidas Salichos William Meyerson Jonathan Warrell Mark Gerstein
author_facet	Leonidas Salichos William Meyerson Jonathan Warrell Mark Gerstein
author_sort	Leonidas Salichos
title	Estimating growth patterns and driver effects in tumor evolution from individual samples
title_short	Estimating growth patterns and driver effects in tumor evolution from individual samples
title_full	Estimating growth patterns and driver effects in tumor evolution from individual samples
title_fullStr	Estimating growth patterns and driver effects in tumor evolution from individual samples
title_full_unstemmed	Estimating growth patterns and driver effects in tumor evolution from individual samples
title_sort	estimating growth patterns and driver effects in tumor evolution from individual samples
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c6a5bf56eac4983a05e8f4f824a7d1c
work_keys_str_mv	AT leonidassalichos estimatinggrowthpatternsanddrivereffectsintumorevolutionfromindividualsamples AT williammeyerson estimatinggrowthpatternsanddrivereffectsintumorevolutionfromindividualsamples AT jonathanwarrell estimatinggrowthpatternsanddrivereffectsintumorevolutionfromindividualsamples AT markgerstein estimatinggrowthpatternsanddrivereffectsintumorevolutionfromindividualsamples
_version_	1718385993549086720

Estimating growth patterns and driver effects in tumor evolution from individual samples

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