Blockade of IL-6/IL-6R Signaling Attenuates Acute Antibody-Mediated Rejection in a Mouse Cardiac Transplantation Model

Blockade of IL-6/IL-6R Signaling Attenuates Acute Antibody-Mediated Rejection in a Mouse Cardiac Transplantation Model

Acute antibody-mediated rejection (AAMR) is an important cause of cardiac allograft dysfunction, and more effective strategies need to be explored to improve allograft prognosis. Interleukin (IL)-6/IL-6R signaling plays a key role in the activation of immune cells including B cells, T cells and macr...

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Autores principales: Maolin Ma, Qipeng Sun, Xiujie Li, Gengguo Deng, Yannan Zhang, Zhe Yang, Fei Han, Zhengyu Huang, Youqiang Fang, Tao Liao, Qiquan Sun
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
antibody-mediated rejection
IL-6
IL-6R
mouse model
cardiac transplantation
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/6c72b2a0905a448894ce4f8dc24281b1
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https://doaj.org/article/6c72b2a0905a448894ce4f8dc24281b1

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