Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased...

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Autores principales: Argel Aguilar-Valles, Nabila Haji, Danilo De Gregorio, Edna Matta-Camacho, Mohammad J. Eslamizade, Jelena Popic, Vijendra Sharma, Ruifeng Cao, Christoph Rummel, Arnaud Tanti, Shane Wiebe, Nicolas Nuñez, Stefano Comai, Robert Nadon, Giamal Luheshi, Naguib Mechawar, Gustavo Turecki, Jean-Claude Lacaille, Gabriella Gobbi, Nahum Sonenberg
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6c8c40fd50844d9c931d779f8d2738c8
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spelling oai:doaj.org-article:6c8c40fd50844d9c931d779f8d2738c82021-12-02T13:24:24ZTranslational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E10.1038/s41467-018-04883-52041-1723https://doaj.org/article/6c8c40fd50844d9c931d779f8d2738c82018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04883-5https://doaj.org/toc/2041-1723Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased IkBα expression; furthermore TNFα delivery to the medial prefrontal cortex induces depression-like behaviour and deficits in serotonergic transmission.Argel Aguilar-VallesNabila HajiDanilo De GregorioEdna Matta-CamachoMohammad J. EslamizadeJelena PopicVijendra SharmaRuifeng CaoChristoph RummelArnaud TantiShane WiebeNicolas NuñezStefano ComaiRobert NadonGiamal LuheshiNaguib MechawarGustavo TureckiJean-Claude LacailleGabriella GobbiNahum SonenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Argel Aguilar-Valles
Nabila Haji
Danilo De Gregorio
Edna Matta-Camacho
Mohammad J. Eslamizade
Jelena Popic
Vijendra Sharma
Ruifeng Cao
Christoph Rummel
Arnaud Tanti
Shane Wiebe
Nicolas Nuñez
Stefano Comai
Robert Nadon
Giamal Luheshi
Naguib Mechawar
Gustavo Turecki
Jean-Claude Lacaille
Gabriella Gobbi
Nahum Sonenberg
Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
description Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased IkBα expression; furthermore TNFα delivery to the medial prefrontal cortex induces depression-like behaviour and deficits in serotonergic transmission.
format article
author Argel Aguilar-Valles
Nabila Haji
Danilo De Gregorio
Edna Matta-Camacho
Mohammad J. Eslamizade
Jelena Popic
Vijendra Sharma
Ruifeng Cao
Christoph Rummel
Arnaud Tanti
Shane Wiebe
Nicolas Nuñez
Stefano Comai
Robert Nadon
Giamal Luheshi
Naguib Mechawar
Gustavo Turecki
Jean-Claude Lacaille
Gabriella Gobbi
Nahum Sonenberg
author_facet Argel Aguilar-Valles
Nabila Haji
Danilo De Gregorio
Edna Matta-Camacho
Mohammad J. Eslamizade
Jelena Popic
Vijendra Sharma
Ruifeng Cao
Christoph Rummel
Arnaud Tanti
Shane Wiebe
Nicolas Nuñez
Stefano Comai
Robert Nadon
Giamal Luheshi
Naguib Mechawar
Gustavo Turecki
Jean-Claude Lacaille
Gabriella Gobbi
Nahum Sonenberg
author_sort Argel Aguilar-Valles
title Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
title_short Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
title_full Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
title_fullStr Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
title_full_unstemmed Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
title_sort translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4e
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6c8c40fd50844d9c931d779f8d2738c8
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