Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.
<h4>Background</h4>Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage. The mechanisms underlying...
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Autores principales: | Ana Lúcia Mena, Eric W-F Lam, Sukalyan Chatterjee |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/6cbeb95a029543c4ba9004c19b55beb2 |
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