Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed p...

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Autores principales: Chang Xu, Wen-Hao Guo, Xu He, Yin-Long Guo, Xue-Ying Zhang, Xingang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6cc8894e17964b75b809104e2d8eb40e
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