Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed p...

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Autores principales:	Chang Xu, Wen-Hao Guo, Xu He, Yin-Long Guo, Xue-Ying Zhang, Xingang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cc8894e17964b75b809104e2d8eb40e
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spelling	oai:doaj.org-article:6cc8894e17964b75b809104e2d8eb40e2021-12-02T17:31:29ZDifluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel10.1038/s41467-018-03532-12041-1723https://doaj.org/article/6cc8894e17964b75b809104e2d8eb40e2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03532-1https://doaj.org/toc/2041-1723Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed pharmaceuticals.Chang XuWen-Hao GuoXu HeYin-Long GuoXue-Ying ZhangXingang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
description	Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed pharmaceuticals.
format	article
author	Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang
author_facet	Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang
author_sort	Chang Xu
title	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_short	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_full	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_fullStr	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_full_unstemmed	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_sort	difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6cc8894e17964b75b809104e2d8eb40e
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Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

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