Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

Abstract Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular homeostasis by regulating a variety of cellular proces...

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Autores principales: Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6ccf7a040ef74caca19da73a1a727ed2
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