Chiral Resolution, Absolute Configuration Assignment, and Genotoxicity Evaluation of Racemic 3,4-Dihydroquinazoline as a Novel Anticancer Agent
If a new drug candidate will be a mixture of enantiomers, both enantiomers should be separately studied for at least latent genotoxicity as early as possible since the thalidomide tragedy. Our group has recently reported that KCP-10043F (OZ-001) as a racemate (±)-3,4-dihydroquinazoline derivative st...
Guardado en:
Autores principales: | Junseong Ahn, Dohyeong Ko, Seyoung Yang, Kwang H. Moon, Jiwon Woo, Ho Yoo, Joohoon Ahn, Jeong H. Lee, Kyung S. Chung, Kyung-T. Lee, Jae Y. Lee |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Hindawi Limited
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6cdb29ca810b425c8948cc86c2aa4421 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
ABSOLUTE CONFIGURATION ASSIGNMENT IN RACEMIC trans-STILBENE OXIDE USING CHIRAL LIQUID CHROMATOGRAPHY WITH COMBINED CHIROPTICAL DETECTION AND TIME-DEPENDENT DENSITY FUNCTIONAL THEORY CALCULATIONS
por: CASTILLO-GONZÁLEZ,JUAN P, et al.
Publicado: (2016) -
Assigning the absolute configuration of single aliphatic molecules by visual inspection
por: Daniel Ebeling, et al.
Publicado: (2018) -
CHIRAL CHROMATOGRAPHIC ANALYSIS AND ABSOLUTE STEREOCHEMISTRY OF RACEMIC CHLORPHENERAMINE USING CHIRAL HPLC-CD-OR AND TD-DFT CALCULATIONS
por: Muñoz,Marcelo A.
Publicado: (2018) -
ABSOLUTE CONFIGURATION OF MULINOLIC ACID
por: BRITO,IVÁN, et al.
Publicado: (2017) -
Absolute configuration and host-guest binding of chiral porphyrin-cages by a combined chiroptical and theoretical approach
por: Jiangkun Ouyang, et al.
Publicado: (2020)