IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory re...

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Main Authors: Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
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https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20

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