IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory re...

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Autores principales: Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
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spelling oai:doaj.org-article:6cf86ce31a16462e8d6947a6f2906f202021-12-02T17:06:18ZIL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression10.1038/ncomms155082041-1723https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f202017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15508https://doaj.org/toc/2041-1723NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.Chenhui WangCun-Jin ZhangBradley N. MartinKatarzyna BulekZizhen KangJunjie ZhaoGuanglin BianJulie A. CarmanJi GaoAshok DongreHaibo XueStephen D. MillerYoucun QianDolores HambardzumyanTom HamiltonRichard M. RansohoffXiaoxia LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
description NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.
format article
author Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
author_facet Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
author_sort Chenhui Wang
title IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_short IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_full IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_fullStr IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_full_unstemmed IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_sort il-17 induced notch1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
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