PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2

PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2

Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently upregulated in colorectal cancer (CRC) samples and ass...

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Autores principales: Yue Chang, Yulu Zhao, Liya Wang, Meijuan Wu, Chenglong He, Mengxi Huang, Zengjie Lei, Jiahe Yang, Siqi Han, Bibo Wang, Yanyan Chen, Chao Liu, Hongju Yu, Lijun Xue, Jian Geng, Yanan Chen, Tingting Dai, Lili Ren, Qian Wang, Xiaobei Liu, Xiaoyuan Chu, Cheng Chen
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
alternative splicing
PHF5A
colorectal cancer
TEAD2
therapeutic target
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/6cfb8d68c577471dba8182838bbac540
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https://doaj.org/article/6cfb8d68c577471dba8182838bbac540

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