Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study

Enhanced activity of the glutamatergic system has been linked to migraine pathophysiology. The present study aimed to assess the involvement of the glutamatergic system in the onset of attacks. We provoked attacks by infusion of glyceryl trinitrate (GTN; 0.5 µg/kg/min over 20 min) in 24 female episo...

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Autores principales:	Gerrit L.J. Onderwater, Jannie P. Wijnen, Chloé Najac, Robin M. van Dongen, Itamar Ronen, Andrew Webb, Ronald Zielman, Erik W. van Zwet, Michel D. Ferrari, Hermien E. Kan, Mark C. Kruit, Gisela M. Terwindt
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Migraine Glutamate GABA Magnetic resonance spectroscopy Glyceryl trinitrate Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6d0bb6880d1d42249173dbcdc062378b
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spelling	oai:doaj.org-article:6d0bb6880d1d42249173dbcdc062378b2021-12-02T05:01:29ZCortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study2213-158210.1016/j.nicl.2021.102889https://doaj.org/article/6d0bb6880d1d42249173dbcdc062378b2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003338https://doaj.org/toc/2213-1582Enhanced activity of the glutamatergic system has been linked to migraine pathophysiology. The present study aimed to assess the involvement of the glutamatergic system in the onset of attacks. We provoked attacks by infusion of glyceryl trinitrate (GTN; 0.5 µg/kg/min over 20 min) in 24 female episodic migraineurs without aura and 13 female age-matched healthy controls. Over the course of a single day participants were scanned three times at fixed time slots (baseline before GTN infusion, 90 min and 270 min after start of GTN infusion). Single-volume proton magnetic resonance spectra (1H–MRS) were acquired at 7 Tesla from a volume of interest (VOI, 2x2x3 cm) in the visual cortex. We assessed the concentrations of glutamate, its major precursor glutamine, and its product gamma-aminobutyric acid (GABA) over the course of a provoked attack. The preictal state was defined as the period after GTN infusion until the migraine-like headache started, independent of possible experienced premonitory symptoms, and the ictal state was defined as the period with provoked migraine-like headache. Data were analyzed using a linear mixed-effect model for repeated measures. Glutamate and glutamine levels did not change from interictal to the preictal and ictal state. GABA levels increased from interictal towards the preictal state for migraine patients compared with healthy controls. We conclude that high resolution 7T MRS is able to show changes in the glutamatergic system towards a triggered migraine attack, by revealing an increased GABA concentration associated with the onset of a migraine attack.Gerrit L.J. OnderwaterJannie P. WijnenChloé NajacRobin M. van DongenItamar RonenAndrew WebbRonald ZielmanErik W. van ZwetMichel D. FerrariHermien E. KanMark C. KruitGisela M. TerwindtElsevierarticleMigraineGlutamateGABAMagnetic resonance spectroscopyGlyceryl trinitrateComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102889- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Migraine Glutamate GABA Magnetic resonance spectroscopy Glyceryl trinitrate Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Migraine Glutamate GABA Magnetic resonance spectroscopy Glyceryl trinitrate Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Gerrit L.J. Onderwater Jannie P. Wijnen Chloé Najac Robin M. van Dongen Itamar Ronen Andrew Webb Ronald Zielman Erik W. van Zwet Michel D. Ferrari Hermien E. Kan Mark C. Kruit Gisela M. Terwindt Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
description	Enhanced activity of the glutamatergic system has been linked to migraine pathophysiology. The present study aimed to assess the involvement of the glutamatergic system in the onset of attacks. We provoked attacks by infusion of glyceryl trinitrate (GTN; 0.5 µg/kg/min over 20 min) in 24 female episodic migraineurs without aura and 13 female age-matched healthy controls. Over the course of a single day participants were scanned three times at fixed time slots (baseline before GTN infusion, 90 min and 270 min after start of GTN infusion). Single-volume proton magnetic resonance spectra (1H–MRS) were acquired at 7 Tesla from a volume of interest (VOI, 2x2x3 cm) in the visual cortex. We assessed the concentrations of glutamate, its major precursor glutamine, and its product gamma-aminobutyric acid (GABA) over the course of a provoked attack. The preictal state was defined as the period after GTN infusion until the migraine-like headache started, independent of possible experienced premonitory symptoms, and the ictal state was defined as the period with provoked migraine-like headache. Data were analyzed using a linear mixed-effect model for repeated measures. Glutamate and glutamine levels did not change from interictal to the preictal and ictal state. GABA levels increased from interictal towards the preictal state for migraine patients compared with healthy controls. We conclude that high resolution 7T MRS is able to show changes in the glutamatergic system towards a triggered migraine attack, by revealing an increased GABA concentration associated with the onset of a migraine attack.
format	article
author	Gerrit L.J. Onderwater Jannie P. Wijnen Chloé Najac Robin M. van Dongen Itamar Ronen Andrew Webb Ronald Zielman Erik W. van Zwet Michel D. Ferrari Hermien E. Kan Mark C. Kruit Gisela M. Terwindt
author_facet	Gerrit L.J. Onderwater Jannie P. Wijnen Chloé Najac Robin M. van Dongen Itamar Ronen Andrew Webb Ronald Zielman Erik W. van Zwet Michel D. Ferrari Hermien E. Kan Mark C. Kruit Gisela M. Terwindt
author_sort	Gerrit L.J. Onderwater
title	Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
title_short	Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
title_full	Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
title_fullStr	Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
title_full_unstemmed	Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
title_sort	cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 tesla magnetic resonance spectroscopy study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6d0bb6880d1d42249173dbcdc062378b
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Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study

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