Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations f...

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Autores principales:	Gengjie Jia, Yu Li, Hanxin Zhang, Ishanu Chattopadhyay, Anders Boeck Jensen, David R. Blair, Lea Davis, Peter N. Robinson, Torsten Dahlén, Søren Brunak, Mikael Benson, Gustaf Edgren, Nancy J. Cox, Xin Gao, Andrey Rzhetsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d34b36c86004f14891b25d4276eebf5
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spelling	oai:doaj.org-article:6d34b36c86004f14891b25d4276eebf52021-12-02T14:38:45ZEstimating heritability and genetic correlations from large health datasets in the absence of genetic data10.1038/s41467-019-13455-02041-1723https://doaj.org/article/6d34b36c86004f14891b25d4276eebf52019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13455-0https://doaj.org/toc/2041-1723Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations for thousands of disease pairs.Gengjie JiaYu LiHanxin ZhangIshanu ChattopadhyayAnders Boeck JensenDavid R. BlairLea DavisPeter N. RobinsonTorsten DahlénSøren BrunakMikael BensonGustaf EdgrenNancy J. CoxXin GaoAndrey RzhetskyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
description	Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations for thousands of disease pairs.
format	article
author	Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky
author_facet	Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky
author_sort	Gengjie Jia
title	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_short	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_full	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_fullStr	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_full_unstemmed	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_sort	estimating heritability and genetic correlations from large health datasets in the absence of genetic data
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d34b36c86004f14891b25d4276eebf5
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

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