Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions

Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.

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Autores principales: Can-Can Bao, Hui-Zhen Du, Yan-Long Luo, Bing-Tao Guan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6d4e8cd90c004f758c13bed418ccb01b
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