Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions

Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions

Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.

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Autores principales: Can-Can Bao, Hui-Zhen Du, Yan-Long Luo, Bing-Tao Guan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/6d4e8cd90c004f758c13bed418ccb01b
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spelling oai:doaj.org-article:6d4e8cd90c004f758c13bed418ccb01b2021-12-02T17:37:10ZDirect alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions10.1038/s42004-021-00575-22399-3669https://doaj.org/article/6d4e8cd90c004f758c13bed418ccb01b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00575-2https://doaj.org/toc/2399-3669Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.Can-Can BaoHui-Zhen DuYan-Long LuoBing-Tao GuanNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chemistry
QD1-999
spellingShingle Chemistry
QD1-999
Can-Can Bao
Hui-Zhen Du
Yan-Long Luo
Bing-Tao Guan
Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
description Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.
format article
author Can-Can Bao
Hui-Zhen Du
Yan-Long Luo
Bing-Tao Guan
author_facet Can-Can Bao
Hui-Zhen Du
Yan-Long Luo
Bing-Tao Guan
author_sort Can-Can Bao
title Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
title_short Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
title_full Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
title_fullStr Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
title_full_unstemmed Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
title_sort direct alkylation of n,n-dialkyl benzamides with methyl sulfides under transition metal-free conditions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6d4e8cd90c004f758c13bed418ccb01b
work_keys_str_mv AT cancanbao directalkylationofnndialkylbenzamideswithmethylsulfidesundertransitionmetalfreeconditions
AT huizhendu directalkylationofnndialkylbenzamideswithmethylsulfidesundertransitionmetalfreeconditions
AT yanlongluo directalkylationofnndialkylbenzamideswithmethylsulfidesundertransitionmetalfreeconditions
AT bingtaoguan directalkylationofnndialkylbenzamideswithmethylsulfidesundertransitionmetalfreeconditions
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