Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors

York et al employ lattice light-sheet microscopy to study the initial events following activation of the epidermal growth factor receptor (EGFR) in whole live cells. They find that APPL1 relocates from pre-existing endosomes, triggered by calcium, to EGFR puncta which results in a cohort, dynein med...

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Autores principales:	H. M. York, A. Patil, U. K. Moorthi, A. Kaur, A. Bhowmik, G. J. Hyde, H. Gandhi, A. Fulcher, K. Gaus, S. Arumugam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6d8be203c19f405a981ea451a9628361
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spelling	oai:doaj.org-article:6d8be203c19f405a981ea451a96283612021-12-02T10:54:14ZRapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors10.1038/s42003-021-01740-y2399-3642https://doaj.org/article/6d8be203c19f405a981ea451a96283612021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01740-yhttps://doaj.org/toc/2399-3642York et al employ lattice light-sheet microscopy to study the initial events following activation of the epidermal growth factor receptor (EGFR) in whole live cells. They find that APPL1 relocates from pre-existing endosomes, triggered by calcium, to EGFR puncta which results in a cohort, dynein mediated movement of EGFR towards the peri-nuclear region of the cell, expanding our understanding of EGFR trafficking dynamics.H. M. YorkA. PatilU. K. MoorthiA. KaurA. BhowmikG. J. HydeH. GandhiA. FulcherK. GausS. ArumugamNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 H. M. York A. Patil U. K. Moorthi A. Kaur A. Bhowmik G. J. Hyde H. Gandhi A. Fulcher K. Gaus S. Arumugam Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
description	York et al employ lattice light-sheet microscopy to study the initial events following activation of the epidermal growth factor receptor (EGFR) in whole live cells. They find that APPL1 relocates from pre-existing endosomes, triggered by calcium, to EGFR puncta which results in a cohort, dynein mediated movement of EGFR towards the peri-nuclear region of the cell, expanding our understanding of EGFR trafficking dynamics.
format	article
author	H. M. York A. Patil U. K. Moorthi A. Kaur A. Bhowmik G. J. Hyde H. Gandhi A. Fulcher K. Gaus S. Arumugam
author_facet	H. M. York A. Patil U. K. Moorthi A. Kaur A. Bhowmik G. J. Hyde H. Gandhi A. Fulcher K. Gaus S. Arumugam
author_sort	H. M. York
title	Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
title_short	Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
title_full	Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
title_fullStr	Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
title_full_unstemmed	Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
title_sort	rapid whole cell imaging reveals a calcium-appl1-dynein nexus that regulates cohort trafficking of stimulated egf receptors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d8be203c19f405a981ea451a9628361
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Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors

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