Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog

Abstract Decreasing the partition coefficient (LogP) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. Since melting point is related to aqueous solubility, we and other groups have developed...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Junki Morimoto, Kazunori Miyamoto, Yuki Ichikawa, Masanobu Uchiyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/6da4c61e46e044feab315317688174ce
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!