The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing...

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Auteurs principaux: Saikat Bhattacharya, Michaella J. Levy, Ning Zhang, Hua Li, Laurence Florens, Michael P. Washburn, Jerry L. Workman
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/6db6754e3f87458799ecf2ba07fc8763
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