The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing...

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Auteurs principaux: Saikat Bhattacharya, Michaella J. Levy, Ning Zhang, Hua Li, Laurence Florens, Michael P. Washburn, Jerry L. Workman
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/6db6754e3f87458799ecf2ba07fc8763
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spelling oai:doaj.org-article:6db6754e3f87458799ecf2ba07fc87632021-12-02T13:32:57ZThe methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain10.1038/s41467-021-21663-w2041-1723https://doaj.org/article/6db6754e3f87458799ecf2ba07fc87632021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21663-whttps://doaj.org/toc/2041-1723The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing machineries.Saikat BhattacharyaMichaella J. LevyNing ZhangHua LiLaurence FlorensMichael P. WashburnJerry L. WorkmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Saikat Bhattacharya
Michaella J. Levy
Ning Zhang
Hua Li
Laurence Florens
Michael P. Washburn
Jerry L. Workman
The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
description The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing machineries.
format article
author Saikat Bhattacharya
Michaella J. Levy
Ning Zhang
Hua Li
Laurence Florens
Michael P. Washburn
Jerry L. Workman
author_facet Saikat Bhattacharya
Michaella J. Levy
Ning Zhang
Hua Li
Laurence Florens
Michael P. Washburn
Jerry L. Workman
author_sort Saikat Bhattacharya
title The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_short The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_full The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_fullStr The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_full_unstemmed The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_sort methyltransferase setd2 couples transcription and splicing by engaging mrna processing factors through its shi domain
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6db6754e3f87458799ecf2ba07fc8763
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