The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing...

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Autores principales:	Saikat Bhattacharya, Michaella J. Levy, Ning Zhang, Hua Li, Laurence Florens, Michael P. Washburn, Jerry L. Workman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6db6754e3f87458799ecf2ba07fc8763
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spelling	oai:doaj.org-article:6db6754e3f87458799ecf2ba07fc87632021-12-02T13:32:57ZThe methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain10.1038/s41467-021-21663-w2041-1723https://doaj.org/article/6db6754e3f87458799ecf2ba07fc87632021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21663-whttps://doaj.org/toc/2041-1723The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing machineries.Saikat BhattacharyaMichaella J. LevyNing ZhangHua LiLaurence FlorensMichael P. WashburnJerry L. WorkmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saikat Bhattacharya Michaella J. Levy Ning Zhang Hua Li Laurence Florens Michael P. Washburn Jerry L. Workman The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
description	The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing machineries.
format	article
author	Saikat Bhattacharya Michaella J. Levy Ning Zhang Hua Li Laurence Florens Michael P. Washburn Jerry L. Workman
author_facet	Saikat Bhattacharya Michaella J. Levy Ning Zhang Hua Li Laurence Florens Michael P. Washburn Jerry L. Workman
author_sort	Saikat Bhattacharya
title	The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_short	The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_full	The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_fullStr	The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_full_unstemmed	The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
title_sort	methyltransferase setd2 couples transcription and splicing by engaging mrna processing factors through its shi domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6db6754e3f87458799ecf2ba07fc8763
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The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

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