Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase activity is crucial for amatoxin macrocyclizati...

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Autores principales: Clarissa M. Czekster, Hannes Ludewig, Stephen A. McMahon, James H. Naismith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252
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