Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase activity is crucial for amatoxin macrocyclizati...

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Autores principales:	Clarissa M. Czekster, Hannes Ludewig, Stephen A. McMahon, James H. Naismith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252
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spelling	oai:doaj.org-article:6dc005fce7cd4bbe952d36cff34182522021-12-02T15:38:42ZCharacterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates10.1038/s41467-017-00862-42041-1723https://doaj.org/article/6dc005fce7cd4bbe952d36cff34182522017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00862-4https://doaj.org/toc/2041-1723Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase activity is crucial for amatoxin macrocyclization.Clarissa M. CzeksterHannes LudewigStephen A. McMahonJames H. NaismithNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clarissa M. Czekster Hannes Ludewig Stephen A. McMahon James H. Naismith Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
description	Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase activity is crucial for amatoxin macrocyclization.
format	article
author	Clarissa M. Czekster Hannes Ludewig Stephen A. McMahon James H. Naismith
author_facet	Clarissa M. Czekster Hannes Ludewig Stephen A. McMahon James H. Naismith
author_sort	Clarissa M. Czekster
title	Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
title_short	Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
title_full	Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
title_fullStr	Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
title_full_unstemmed	Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
title_sort	characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252
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Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

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