Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

Ying Fei Li,1 Chengyue Zhang,1 Simon Zhou,1 Miao He,2 Huixia Zhang,2 Nianhang Chen,1 Feng Li,2 Xin Luan,2 Manjunath Pai,3 Hebao Yuan,2 Duxin Sun,2 Yan Li1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07901, USA; 2Department of Pharmaceutical Sciences, College...

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Detalles Bibliográficos
Autores principales: Li YF, Zhang C, Zhou S, He M, Zhang H, Chen N, Li F, Luan X, Pai M, Yuan H, Sun D, Li Y
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
paclitaxel
pharmacokinetics
tissue distribution
drug elimination/disposition
species difference
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/6dcbd0e2ae8d45b090423ef06d562f86
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https://doaj.org/article/6dcbd0e2ae8d45b090423ef06d562f86

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