Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer.
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Nature Portfolio
2017
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oai:doaj.org-article:6dd1f31e993c4c649fd8af898835fe412021-12-02T15:38:57ZSynthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer10.1038/s41467-017-00393-y2041-1723https://doaj.org/article/6dd1f31e993c4c649fd8af898835fe412017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00393-yhttps://doaj.org/toc/2041-1723Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer.Mohammad AsimFiras TarishHeather I. ZecchiniKumar SanjivEleni GelaliCharles E. MassieAjoeb BaridiAnne Y. WarrenWanfeng ZhaoChristoph OgrisLeigh-Anne McDuffusPatrice MascalchiGreg ShawHarveer DevKaran WadhwaPaul WijnhovenJosep V. FormentScott R. LyonsAndy G. LynchCormac O’NeillVincent R. ZecchiniPaul S. RennieAria BaniahmadSimon TavaréIan G. MillsYaron GalantyNicola CrosettoNiklas SchultzDavid NealThomas HelledayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mohammad Asim Firas Tarish Heather I. Zecchini Kumar Sanjiv Eleni Gelali Charles E. Massie Ajoeb Baridi Anne Y. Warren Wanfeng Zhao Christoph Ogris Leigh-Anne McDuffus Patrice Mascalchi Greg Shaw Harveer Dev Karan Wadhwa Paul Wijnhoven Josep V. Forment Scott R. Lyons Andy G. Lynch Cormac O’Neill Vincent R. Zecchini Paul S. Rennie Aria Baniahmad Simon Tavaré Ian G. Mills Yaron Galanty Nicola Crosetto Niklas Schultz David Neal Thomas Helleday Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| description |
Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer. |
| format |
article |
| author |
Mohammad Asim Firas Tarish Heather I. Zecchini Kumar Sanjiv Eleni Gelali Charles E. Massie Ajoeb Baridi Anne Y. Warren Wanfeng Zhao Christoph Ogris Leigh-Anne McDuffus Patrice Mascalchi Greg Shaw Harveer Dev Karan Wadhwa Paul Wijnhoven Josep V. Forment Scott R. Lyons Andy G. Lynch Cormac O’Neill Vincent R. Zecchini Paul S. Rennie Aria Baniahmad Simon Tavaré Ian G. Mills Yaron Galanty Nicola Crosetto Niklas Schultz David Neal Thomas Helleday |
| author_facet |
Mohammad Asim Firas Tarish Heather I. Zecchini Kumar Sanjiv Eleni Gelali Charles E. Massie Ajoeb Baridi Anne Y. Warren Wanfeng Zhao Christoph Ogris Leigh-Anne McDuffus Patrice Mascalchi Greg Shaw Harveer Dev Karan Wadhwa Paul Wijnhoven Josep V. Forment Scott R. Lyons Andy G. Lynch Cormac O’Neill Vincent R. Zecchini Paul S. Rennie Aria Baniahmad Simon Tavaré Ian G. Mills Yaron Galanty Nicola Crosetto Niklas Schultz David Neal Thomas Helleday |
| author_sort |
Mohammad Asim |
| title |
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| title_short |
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| title_full |
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| title_fullStr |
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| title_full_unstemmed |
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer |
| title_sort |
synthetic lethality between androgen receptor signalling and the parp pathway in prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6dd1f31e993c4c649fd8af898835fe41 |
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