Phylogenetic quantification of intra-tumour heterogeneity.

Intra-tumour genetic heterogeneity is the result of ongoing evolutionary change within each cancer. The expansion of genetically distinct sub-clonal populations may explain the emergence of drug resistance, and if so, would have prognostic and predictive utility. However, methods for objectively qua...

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Autores principales: Roland F Schwarz, Anne Trinh, Botond Sipos, James D Brenton, Nick Goldman, Florian Markowetz
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/6dd413daf5624a3ca6cb2ee07f8518da
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